Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 7/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | LCK | P06239 | 4/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205520 | 1.00 | IKBKE (0.38) | IKBKETBK1SYKJAK3FLT3 | |
| SCHEMBL24944990 | 0.95 | IKBKE (0.44) | IKBKETBK1SYKFLT3EGFR | |
| SCHEMBL30205756 | 0.95 | IKBKE (0.44) | IKBKETBK1SYKFLT3EGFR | |
| SCHEMBL29173589 | 0.92 | FLT3 (0.36) | SYKFLT3CCNCCDK8PDGFRA | |
| SCHEMBL24944172 | 0.89 | TBK1 (0.39) | IKBKETBK1SYKFLT3BTK | |
| Formic Acid SCHEMBL30205666 | 0.86 | TBK1 (0.37) | IKBKETBK1SYKFLT3BTK | |
| SCHEMBL29173673 | 0.86 | FLT3 (0.39) | IKBKETBK1FLT3MELK | |
| SCHEMBL24944415 | 0.84 | BTK (0.37) | SYKJAK3FLT3EGFRLCK | |
| SCHEMBL30206104 | 0.84 | BTK (0.37) | SYKJAK3FLT3EGFRLCK | |
| SCHEMBL24943840 | 0.84 | IKBKE (0.46) | IKBKETBK1SYKFLT3EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |