Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 7/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205756 | 1.00 | IKBKE (0.44) | IKBKETBK1FLT3EGFRAXL | |
| SCHEMBL24944456 | 0.95 | IKBKE (0.38) | IKBKETBK1FLT3EGFRSYK | |
| SCHEMBL30205520 | 0.95 | IKBKE (0.38) | IKBKETBK1FLT3EGFRSYK | |
| SCHEMBL29173673 | 0.92 | FLT3 (0.39) | IKBKETBK1FLT3AXLMELK | |
| SCHEMBL30205589 | 0.89 | IKBKE (0.46) | IKBKETBK1FLT3AXLSYK | |
| SCHEMBL24943840 | 0.89 | IKBKE (0.46) | IKBKETBK1FLT3AXLSYK | |
| SCHEMBL24944440 | 0.88 | IKBKE (0.44) | IKBKETBK1AXLALKTNIK | |
| SCHEMBL30205592 | 0.88 | IKBKE (0.44) | IKBKETBK1AXLALKTNIK | |
| SCHEMBL24943838 | 0.87 | TBK1 (0.46) | IKBKETBK1FLT3AXLEML4 | |
| SCHEMBL30205580 | 0.87 | TBK1 (0.46) | IKBKETBK1FLT3AXLEML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |