Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 5/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 9/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.45 |
| ▸ | ROS1 | P08922 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205535 | 1.00 | EML4 (0.51) | EML4ALKCDK2AURKACCNA2 | |
| SCHEMBL29173496 | 0.92 | EML4 (0.42) | EML4ALKCDK2AURKACCNA2 | |
| SCHEMBL24944782 | 0.91 | RET (0.49) | EML4ALKCDK2AURKACCNA2 | |
| SCHEMBL24944461 | 0.86 | EML4 (0.42) | EML4ALKROS1FLT3SYK | |
| SCHEMBL24943828 | 0.85 | CDK2 (0.37) | CDK2AURKACCNA2CCNA1SYK | |
| SCHEMBL30205989 | 0.84 | CDK2 (0.40) | EML4ALKCDK2CCNA2CCNA1 | |
| SCHEMBL29173447 | 0.84 | CDK2 (0.40) | EML4ALKCDK2CCNA2CCNA1 | |
| Formic Acid SCHEMBL30205508 | 0.84 | EML4 (0.40) | EML4ALKROS1FLT3SYK | |
| Formic Acid SCHEMBL29173289 | 0.84 | EML4 (0.40) | EML4ALKROS1FLT3SYK | |
| SCHEMBL24944209 | 0.84 | SYK (0.44) | EML4ALKCDK2AURKACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |