Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 10/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.38 |
| ▸ | CDK1 | P06493 | 7/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.38 |
| ▸ | CDK7 | P50613 | 7/20 | 0.38 |
| ▸ | CCNH | P51946 | 7/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205989 | 1.00 | CDK2 (0.40) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL29173496 | 0.93 | EML4 (0.42) | CDK2CCNA2CDK9CCNT1CDK1 | |
| SCHEMBL29173546 | 0.88 | JAK2 (0.42) | CDK2CCNA2CCND3CDK6CDK9 | |
| SCHEMBL30206211 | 0.88 | JAK2 (0.42) | CDK2CCNA2CCND3CDK6CDK9 | |
| SCHEMBL29173534 | 0.86 | ALK (0.36) | ALKEGFRJAK2JAK3PTK2 | |
| SCHEMBL24944460 | 0.84 | EML4 (0.51) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL30205535 | 0.84 | EML4 (0.51) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL29173378 | 0.84 | CYP1A2 (0.35) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL30206107 | 0.84 | CYP1A2 (0.35) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL29173512 | 0.82 | PKMYT1 (0.40) | CDK2CCNA2CDK4CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |