Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | CCNC | P24863 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24944495 | 0.94 | TLR7 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL30206277 | 0.94 | LRRK2 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL30206282 | 0.94 | LRRK2 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL24944493 | 0.94 | TLR7 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL30206258 | 0.94 | TLR7 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL24944781 | 0.94 | TLR7 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL30205936 | 0.94 | TLR7 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL24944780 | 0.83 | LRRK2 (0.34) | TLR7LRRK2CCNCCDK8 | |
| SCHEMBL30206270 | 0.83 | LRRK2 (0.36) | TLR7LRRK2CCNCCDK8WNT3A | |
| SCHEMBL30205960 | 0.83 | LRRK2 (0.34) | TLR7LRRK2CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |