Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | CCNC | P24863 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24944783 | 0.92 | LRRK2 (0.41) | LRRK2EGFRCCNCCDK8SYK | |
| SCHEMBL30205579 | 0.92 | SYK (0.44) | CCNCCDK8SYKALKPDGFRA | |
| SCHEMBL24944183 | 0.92 | SYK (0.44) | CCNCCDK8SYKALKPDGFRA | |
| SCHEMBL24944496 | 0.91 | LRRK2 (0.36) | LRRK2EGFRCCNCCDK8ALK | |
| Formic Acid SCHEMBL29173332 | 0.90 | LRRK2 (0.39) | LRRK2EGFRCCNCCDK8SYK | |
| Formic Acid SCHEMBL30205467 | 0.90 | LRRK2 (0.39) | LRRK2EGFRCCNCCDK8SYK | |
| Formic Acid SCHEMBL30205591 | 0.89 | LRRK2 (0.35) | LRRK2EGFRCCNCCDK8ALK | |
| SCHEMBL24943795 | 0.89 | MAPK9 (0.44) | LRRK2EGFRSYKIGF1RKCNH2 | |
| SCHEMBL24944784 | 0.86 | LRRK2 (0.36) | LRRK2EGFRCCNCCDK8SYK | |
| SCHEMBL30205495 | 0.86 | LRRK2 (0.36) | LRRK2EGFRCCNCCDK8SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |