Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 10/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.36 |
| ▸ | RET | P07949 | 10/20 | 0.35 |
| ▸ | ROS1 | P08922 | 10/20 | 0.35 |
| ▸ | FLT3 | P36888 | 10/20 | 0.35 |
| ▸ | SYK | P43405 | 5/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205565 | 0.91 | EML4 (0.40) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24943820 | 0.89 | ATM (0.36) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944958 | 0.89 | ATM (0.36) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944962 | 0.89 | ATM (0.36) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30206167 | 0.87 | EML4 (0.41) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944779 | 0.87 | FGFR4 (0.35) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30205785 | 0.87 | FGFR4 (0.35) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944458 | 0.87 | FGFR4 (0.35) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944455 | 0.87 | FGFR4 (0.35) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944410 | 0.85 | RET (0.38) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |