Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 8/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.41 |
| ▸ | RET | P07949 | 11/20 | 0.40 |
| ▸ | ROS1 | P08922 | 11/20 | 0.40 |
| ▸ | FLT3 | P36888 | 11/20 | 0.40 |
| ▸ | SYK | P43405 | 6/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205565 | 0.96 | EML4 (0.40) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30205996 | 0.92 | LRRK2 (0.36) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944971 | 0.90 | RET (0.41) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30205554 | 0.90 | RET (0.41) | EML4ALKRETROS1FLT3 | |
| SCHEMBL29173301 | 0.89 | BTK (0.39) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30206228 | 0.88 | ALK (0.33) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24943791 | 0.88 | EML4 (0.48) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944723 | 0.87 | EML4 (0.36) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944782 | 0.87 | RET (0.49) | EML4ALKRETROS1FLT3 | |
| Formic Acid SCHEMBL30205747 | 0.86 | BTK (0.37) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | claimed |
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | claimed |
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |