Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 5/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205575 | 1.00 | EGFR (0.41) | EGFRLCKJAK3BTKCDK2 | |
| Formic Acid SCHEMBL30206333 | 0.97 | EGFR (0.39) | EGFRLCKJAK3BTKCDK2 | |
| SCHEMBL24944404 | 0.88 | SYK (0.34) | EGFRLCKJAK3BTKCDK2 | |
| SCHEMBL29173296 | 0.88 | EML4 (0.33) | EML4ALKPDE4BRETROS1 | |
| SCHEMBL24944178 | 0.87 | BTK (0.43) | EGFRLCKJAK3BTKCDK2 | |
| SCHEMBL24943828 | 0.87 | CDK2 (0.37) | LCKJAK3BTKCDK2CCNA2 | |
| SCHEMBL30206306 | 0.86 | EML4 (0.33) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944172 | 0.86 | TBK1 (0.39) | BTKEML4ALKPDE4BRET | |
| SCHEMBL24943840 | 0.85 | IKBKE (0.46) | CDK2CCNA2CCNA1EML4ALK | |
| SCHEMBL30205589 | 0.85 | IKBKE (0.46) | CDK2CCNA2CCNA1EML4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |