Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206109 | 1.00 | LRRK2 (0.43) | LRRK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL29173326 | 0.93 | ALK (0.36) | LRRK2EGFRCHEK1 | |
| SCHEMBL30206025 | 0.93 | ALK (0.36) | LRRK2EGFRCHEK1 | |
| SCHEMBL24944783 | 0.92 | LRRK2 (0.41) | LRRK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL30206021 | 0.92 | LRRK2 (0.40) | LRRK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL29173398 | 0.92 | LRRK2 (0.40) | LRRK2JAK2JAK1TYK2JAK3 | |
| Formic Acid SCHEMBL30205467 | 0.90 | LRRK2 (0.39) | LRRK2JAK2JAK1TYK2JAK3 | |
| Formic Acid SCHEMBL29173332 | 0.90 | LRRK2 (0.39) | LRRK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL29173415 | 0.89 | CCNC (0.42) | LRRK2CCNCCDK8EGFRSYK | |
| SCHEMBL29173445 | 0.88 | ZAP70 (0.43) | LRRK2JAK2EGFRCHEK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |