Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | EML4 | Q9HC35 | 9/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.33 |
| ▸ | RET | P07949 | 9/20 | 0.33 |
| ▸ | ROS1 | P08922 | 9/20 | 0.33 |
| ▸ | FLT3 | P36888 | 9/20 | 0.33 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205470 | 1.00 | PSEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29173390 | 0.91 | PSEN1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL24943828 | 0.85 | CDK2 (0.37) | SYK | |
| SCHEMBL30206306 | 0.85 | EML4 (0.33) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30205499 | 0.85 | TYK2 (0.37) | EML4ALKSYK | |
| SCHEMBL24944982 | 0.85 | TYK2 (0.37) | EML4ALKSYK | |
| SCHEMBL24944782 | 0.85 | RET (0.49) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944209 | 0.84 | SYK (0.44) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30205569 | 0.84 | SYK (0.44) | EML4ALKRETROS1FLT3 | |
| Hydrochloric Acid SCHEMBL30206015 | 0.84 | EML4 (0.33) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |