Triaziquone

Triaziquone

SCHEMBL249462

O=C([O-])C(F)(F)F.O=C1C=C(N2CC2)C(=O)C(N2CC2)=C1N1CC1.[Tl+]

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 1/20 0.36
TP53 P04637 1/20 0.34
MAPT P10636 1/20 0.34
STAT3 P40763 1/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
APAF1 O14727 1/20 0.30
TDP2 O95551 1/20 0.30
NSD2 O96028 1/20 0.30
HKDC1 Q2TB90 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triaziquone SCHEMBL1462397 0.87 DNMT1 (0.38) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL15269829 0.86 DNMT1 (0.37) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL6009839 0.82 DNMT1 (0.34) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL3528984 0.81 CA4 (0.46) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL4608905 0.81 DNMT1 (0.43) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL8303 0.81 DNMT1 (0.48) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL1869724 0.81 DNMT1 (0.38) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL20742268 0.81 MAPT (0.39) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL5390252 0.81 MAPT (0.39) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL2732789 0.80 CA4 (0.45) DNMT1TP53MAPTSTAT3HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012001308-A9 METHOD FOR SYNTHESIZING ERGOLINE ALKALOIDS FROM INDOLIC BICYCLIC COMPOUNDS BY DOUBLE CYCLIZATION, RESULTING MATERIALS, AND INTERMEDIATE MATERIALS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-03-22 WO disclosed
WO-2012001308-A1 METHOD FOR SYNTHESIZING ERGOLINE ALKALOIDS FROM INDOLIC BICYCLIC COMPOUNDS BY DOUBLE CYCLIZATION, RESULTING MATERIALS, AND INTERMEDIATE MATERIALS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-01-05 WO disclosed