Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 7/20 | 0.31 |
| ▸ | CES1 | P23141 | 5/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.31 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.31 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24974515 | 0.96 | CES2 (0.39) | CES2LPAR1LPAR3GBA1EPHX1 | |
| SCHEMBL22023883 | 0.96 | CES2 (0.39) | CES2LPAR1LPAR3GBA1EPHX1 | |
| SCHEMBL19245047 | 0.96 | CES2 (0.39) | CES2LPAR1LPAR3GBA1EPHX1 | |
| SCHEMBL21191697 | 0.94 | CES2 (0.38) | CES2LPAR1LPAR3GBA1EPHX1 | |
| SCHEMBL25733300 | 0.83 | GNAO1 (0.35) | EPHX1GNAI3GNAO1GNAI1 | |
| SCHEMBL23896488 | 0.81 | GNAO1 (0.40) | EPHX1GNAI3GNAO1GNAI1 | |
| SCHEMBL23745311 | 0.81 | GNAO1 (0.43) | EPHX1GNAI3GNAO1GNAI1 | |
| SCHEMBL26653352 | 0.81 | GNAO1 (0.40) | EPHX1GNAI3GNAO1GNAI1 | |
| SCHEMBL18459246 | 0.80 | HTR2A (0.32) | GNAI3GNAO1GNAI1 | |
| SCHEMBL19879718 | 0.79 | CES2 (0.34) | CES2LPAR1LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230026611-A1 | ARYL HETEROCYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026611-A1 | ARYL HETEROCYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | KCNA3, KCNH2, KCNJ2 | CES2 2976/4885LPAR1 1708/4885LPAR3 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.