Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2494781 | 0.82 | AVPR1B (0.52) | AVPR1B | |
| SCHEMBL2458842 | 0.77 | AVPR1B (0.41) | AVPR1AMAPTPOLBAVPR1BTLR9 | |
| SCHEMBL4060343 | 0.76 | HTR1A (0.43) | AVPR1ATGFBR1ACVR1ACVRL1AVPR1B | |
| SCHEMBL2461965 | 0.74 | AVPR1B (0.57) | AVPR1B | |
| SCHEMBL2461791 | 0.72 | AVPR1B (0.48) | AVPR1AAVPR1B | |
| SCHEMBL2462290 | 0.72 | AVPR1B (0.51) | AVPR1AAVPR1B | |
| SCHEMBL3452141 | 0.70 | ENPP2 (0.39) | TGFBR1ACVR1ENPP2BMPR1BBMPR1A | |
| SCHEMBL2456669 | 0.70 | AVPR1B (0.66) | AVPR1B | |
| SCHEMBL2456288 | 0.69 | AVPR1B (0.49) | AVPR1AAVPR1B | |
| Acetamide SCHEMBL3452139 | 0.68 | AVPR1B (0.43) | AVPR1AENPP2AVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069315-B1 | QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES | ORGANON NV (NL) | 2011-09-07 | — | — | EP | disclosed |