Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 2/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29742813 | 1.00 | NPC1 (0.56) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL29742828 | 0.87 | MKNK1 (0.45) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL24951909 | 0.87 | MKNK1 (0.45) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL28630958 | 0.85 | NR4A2 (0.50) | KDM4EALDH1A1HSD17B10SMN1; SMN2MAPK1 | |
| SCHEMBL557753 | 0.82 | NPC1 (0.73) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| Acetic Acid SCHEMBL28745643 | 0.80 | NPC1 (0.69) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL28143432 | 0.75 | KMO (0.57) | KDM4EALDH1A1HTTLMNAKMO | |
| SCHEMBL3106911 | 0.75 | CYP3A4 (0.55) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL3649252 | 0.75 | NPC1 (0.57) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL20022402 | 0.73 | IKBKB (0.58) | NPC1RAB9AKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240376091-A1 | THIADIAZOLEAMIDE DERIVATIVES AND THEIR APPLICATIONS | ZHEJIANG UNIVERSITY (CN) | 2024-11-14 | — | — | US | disclosed |
| WO-2023004897-A1 | THIADIAZOLE AMIDE COMPOUND AND USE THEREOF | 浙江大学 | 2023-02-02 | — | — | WO | disclosed |
| WO-2023004897-A1 | THIADIAZOLE AMIDE COMPOUND AND USE THEREOF | 浙江大学 | 2023-02-02 | — | — | WO | disclosed |
| CN-113444081-B | Thiadiazole carboxamide compounds and application thereof | 浙江大学 | 2022-07-05 | — | — | CN | disclosed |
| CN-113444081-A | Thiadiazole amide compound and application thereof | 浙江大学 | 2021-09-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240376091-A1 | THIADIAZOLEAMIDE DERIVATIVES AND THEIR APPLICATIONS | AR, GPER1, CYP19A1 | NPC1 2750/4885RAB9A 3272/4885KDM4E 3144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.