Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249535 | 1.00 | CTSD (0.36) | CTSDCTSLCTSBCTSSHDAC6 | |
| SCHEMBL3221995 | 0.72 | CTSS (0.41) | CTSDCTSLCTSBCTSSHDAC6 | |
| SCHEMBL11029851 | 0.65 | HDAC6 (0.37) | CTSDCTSLCTSBCTSSHDAC6 | |
| SCHEMBL24342349 | 0.65 | TDP1 (0.45) | — | |
| SCHEMBL18493944 | 0.64 | TDP1 (0.37) | HDAC6 | |
| SCHEMBL4726104 | 0.64 | DPP4 (0.49) | CTSDCTSLCTSBCTSSHDAC6 | |
| SCHEMBL8737769 | 0.64 | HDAC6 (0.39) | CTSDCTSLCTSBCTSSHDAC6 | |
| SCHEMBL761358 | 0.64 | HDAC6 (0.39) | CTSDCTSLCTSBCTSSHDAC6 | |
| SCHEMBL15798583 | 0.63 | HDAC6 (0.38) | CTSDCTSLCTSBCTSSHDAC6 | |
| SCHEMBL19400994 | 0.63 | CTSD (0.35) | CTSDCTSLCTSBCTSSHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588465-A1 | SGC STIMULATORS | Ironwood Pharmaceuticals, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003405-A1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-01-05 | — | — | WO | disclosed |