Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497541 | 0.83 | CXCL8 (0.39) | PARP1SMN1; SMN2CYP1A2PDPK1CA12 | |
| SCHEMBL2820813 | 0.78 | CXCL8 (0.40) | PARP1SMN1; SMN2CYP1A2KMT2APDPK1 | |
| SCHEMBL22559041 | 0.77 | CYP1A2 (0.39) | PARP1SMN1; SMN2CYP1A2PDPK1CA12 | |
| SCHEMBL8576522 | 0.76 | CPA1 (0.50) | CYP1A2 | |
| SCHEMBL5324432 | 0.75 | KDM4E (0.46) | MEN1CYP1A2KMT2AALOX15CYP3A4 | |
| SCHEMBL2496165 | 0.75 | KDM4E (0.46) | MEN1CYP1A2KMT2AALOX15CYP3A4 | |
| SCHEMBL2817264 | 0.74 | PARP1 (0.34) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| SCHEMBL7036443 | 0.74 | PARP1 (0.34) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| SCHEMBL7727344 | 0.73 | TAAR1 (0.40) | PARP1SMN1; SMN2CYP1A2PDPK1CA12 | |
| SCHEMBL5322426 | 0.73 | GRM2 (0.42) | MEN1KMT2ACYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373628-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010070021-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-06-24 | — | — | WO | disclosed |