Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | MMP16 | P51512 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820813 | 0.86 | CXCL8 (0.40) | CXCL8PARP1SMN1; SMN2PDPK1CA12 | |
| SCHEMBL2495510 | 0.83 | PARP1 (0.34) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| SCHEMBL7727344 | 0.81 | TAAR1 (0.40) | PARP1PTGS1SMN1; SMN2PDPK1CA12 | |
| SCHEMBL22559041 | 0.78 | CYP1A2 (0.39) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| SCHEMBL8576522 | 0.77 | CPA1 (0.50) | PTGS1CYP1A2 | |
| SCHEMBL2497545 | 0.76 | PARP1 (0.50) | CXCL8PARP1PTGS2 | |
| SCHEMBL14477036 | 0.75 | TSHR (0.42) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| SCHEMBL7036443 | 0.75 | PARP1 (0.34) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| SCHEMBL2817264 | 0.75 | PARP1 (0.34) | PARP1MMP9SMN1; SMN2PDPK1CA12 | |
| SCHEMBL2496016 | 0.74 | PARP1 (0.35) | PARP1SMN1; SMN2PDPK1CA12ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373628-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010070021-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-06-24 | — | — | WO | disclosed |