Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.61 |
| ▸ | DDB1 | Q16531 | 11/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25634636 | 0.81 | CRBN (0.63) | CRBNDDB1ALDH1A1KDM4EHPGD | |
| SCHEMBL22144673 | 0.81 | CRBN (0.67) | CRBNDDB1ALDH1A1KDM4EHPGD | |
| SCHEMBL22119794 | 0.80 | CRBN (0.65) | CRBNDDB1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL30969021 | 0.80 | CRBN (0.65) | CRBNDDB1ALDH1A1KDM4EHPGD | |
| SCHEMBL23984143 | 0.79 | CRBN (0.56) | CRBNDDB1ALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL22119617 | 0.78 | CRBN (0.63) | CRBNDDB1ALDH1A1KDM4E | |
| SCHEMBL24207146 | 0.78 | CRBN (0.63) | CRBNDDB1ALDH1A1KDM4EHPGD | |
| SCHEMBL29007105 | 0.78 | CRBN (0.59) | CRBNDDB1ALDH1A1KDM4EHPGD | |
| SCHEMBL5376083 | 0.77 | CRBN (1.00) | CRBNDDB1ALDH1A1KDM4EHPGD | |
| SCHEMBL24598273 | 0.76 | CRBN (0.52) | CRBNDDB1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006063-A1 | PYRROLO [2, 3-b] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-02-02 | — | — | WO | disclosed |