Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.63 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24678272 | 0.84 | CRBN (0.52) | CRBNDDB1ALDH1A1KDM4EGAA | |
| SCHEMBL22144673 | 0.83 | CRBN (0.67) | CRBNDDB1ALDH1A1KDM4EGAA | |
| SCHEMBL23267981 | 0.83 | CRBN (0.54) | CRBNDDB1ALDH1A1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL30969021 | 0.82 | CRBN (0.65) | CRBNDDB1ALDH1A1KDM4EGAA | |
| SCHEMBL22119794 | 0.82 | CRBN (0.65) | CRBNDDB1ALDH1A1KDM4ESIRT6 | |
| SCHEMBL24955690 | 0.81 | CRBN (0.61) | CRBNDDB1ALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL22119617 | 0.81 | CRBN (0.63) | CRBNDDB1ALDH1A1KDM4ESIRT6 | |
| SCHEMBL29007105 | 0.80 | CRBN (0.59) | CRBNDDB1ALDH1A1KDM4EMAPT | |
| SCHEMBL25818079 | 0.80 | DDB1 (0.50) | CRBNDDB1ALDH1A1KDM4EGAA | |
| SCHEMBL23134713 | 0.80 | CRBN (0.71) | CRBNDDB1ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023093845-A1 | CHIMERIC COMPOUND FOR TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2023-06-01 | — | — | WO | disclosed |