Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 1.00 |
| ▸ | DDB1 | Q16531 | 11/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | G6PD | P11413 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30874155 | 0.98 | CRBN (0.96) | CRBNDDB1ALOX5G6PDALOX15 | |
| SCHEMBL23142732 | 0.90 | CRBN (0.81) | CRBNDDB1ALOX5G6PDALOX15 | |
| SCHEMBL21995508 | 0.89 | CRBN (0.80) | CRBNDDB1ALOX5G6PDALOX15 | |
| SCHEMBL24155474 | 0.85 | CRBN (0.73) | CRBNDDB1ALOX15MAPTTDP1 | |
| SCHEMBL24155535 | 0.85 | CRBN (0.73) | CRBNDDB1GAATNKS | |
| SCHEMBL24156370 | 0.85 | CRBN (0.73) | CRBNDDB1ALOX5G6PDALOX15 | |
| SCHEMBL23983474 | 0.81 | CRBN (0.71) | CRBNDDB1RAB9AKDM4EMAPT | |
| SCHEMBL23120608 | 0.81 | CRBN (0.71) | CRBNDDB1ALOX5KDM4EALDH1A1 | |
| SCHEMBL21995598 | 0.81 | CRBN (0.71) | CRBNDDB1MEN1KMT2AKDM4E | |
| SCHEMBL23134713 | 0.81 | CRBN (0.71) | CRBNDDB1ALOX5KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4673438-A1 | PROTEOLYSIS-TARGETING CHIMERAS | Tocris Cookson Limited (GB) | 2026-01-07 | — | — | EP | claimed |
| CN-120152967-A | Bifunctional compounds containing 2, 5-substituted pyrimidine derivatives for degradation of cyclin-dependent kinase 2 via the ubiquitin proteasome pathway | 霖康疗法公司 | 2025-06-13 | — | — | CN | claimed |
| WO-2024180157-A1 | PROTEOLYSIS-TARGETING CHIMERAS | TOCRIS COOKSON LIMITED (GB) | 2024-09-06 | — | — | WO | claimed |
| US-20070208036-A1 | Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and processes for preparing them | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-09-06 | — | — | US | claimed |
| US-7230001-B1 | Arylalkane, arylalkene and aryl azaalkane, medicaments containing said compounds and method for the production thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-06-12 | — | — | US | claimed |
| JP-63066173-A | — | — | None | — | — | JP | disclosed |
| EP-4673438-A1 | PROTEOLYSIS-TARGETING CHIMERAS | Tocris Cookson Limited (GB) | 2026-01-07 | — | — | EP | disclosed |
| US-20250354195-A1 | METHOD OF SCREENING | UNIV DUNDEE (GB) | 2025-11-20 | — | — | US | disclosed |
| US-20250051320-A1 | CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2025-02-13 | — | — | US | disclosed |
| US-20240400587-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS INC (US) | 2024-12-05 | — | — | US | disclosed |
| WO-2024227104-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BRAF VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2024-10-31 | — | — | WO | disclosed |
| WO-2024180157-A1 | PROTEOLYSIS-TARGETING CHIMERAS | TOCRIS COOKSON LIMITED (GB) | 2024-09-06 | — | — | WO | disclosed |
| US-20200347045-A1 | CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2020-11-05 | — | — | US | disclosed |
| US-10800758-B2 | Pyrimidine compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2020-10-13 | — | — | US | disclosed |
| CN-109641872-A | 3- pyridyl group phenyl dihydrouracil compound and application thereof | 住友化学株式会社 | 2019-04-16 | — | — | CN | disclosed |
| CN-109641872-A | 3- pyridyl group phenyl dihydrouracil compound and application thereof | 住友化学株式会社 | 2019-04-16 | — | — | CN | disclosed |
| US-20070208036-A1 | Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and processes for preparing them | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-09-06 | — | — | US | disclosed |
| US-7230001-B1 | Arylalkane, arylalkene and aryl azaalkane, medicaments containing said compounds and method for the production thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-06-12 | — | — | US | disclosed |
| WO-2004009559-A2 | DIHYDROURACIL COMPOUNDS AS ANTI-ICTOGENIC OR ANTI-EPILEPTOGENIC AGENTS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2004-01-29 | — | — | WO | disclosed |
| JP-S6366173-A | PRODUCTION OF URACIL DERIVATIVE | UENO SEIYAKU OYO KENKYUSHO:KK | 1988-03-24 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200347045-A1 | CRBN LIGANDS AND USES THEREOF | CRBN, CRKL, ERBB3 | CRBN 1/4885DDB1 304/4885ALOX5 4795/4885 |
| US-20070208036-A1 | Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and processes for preparing them | ARRB1, NPY1R, ADRB3 | CRBN 2351/4885DDB1 2631/4885ALOX5 1246/4885 |
| US-20250051320-A1 | CRBN LIGANDS AND USES THEREOF | CRBN, CRKL, ERBB3 | CRBN 1/4885DDB1 304/4885ALOX5 4795/4885 |
| US-10800758-B2 | Pyrimidine compound | UMPS, TPMT, TYMS | CRBN 4450/4885DDB1 2854/4885ALOX5 1795/4885 |
| US-20250354195-A1 | METHOD OF SCREENING | PAICS, COASY, ABCG2 | CRBN 1827/4885DDB1 797/4885ALOX5 3451/4885 |
| US-20240400587-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | TTK, HIPK1, CLK1 | CRBN 218/4885DDB1 675/4885ALOX5 4754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.