Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2611049 | 0.81 | PARP1 (0.46) | PARP1BRD4DRD4DRD3DRD2 | |
| SCHEMBL24351926 | 0.78 | PARP1 (0.44) | PARP1BRD4DRD4DRD3DRD2 | |
| SCHEMBL7856459 | 0.78 | PARP1 (0.47) | PARP1BRD4DRD4DRD3DRD2 | |
| SCHEMBL18713659 | 0.75 | TSHR (0.42) | PARP1BRD4DRD4DRD3DRD2 | |
| SCHEMBL2127998 | 0.75 | PARP1 (0.41) | PARP1BRD4DRD4DRD3DRD2 | |
| SCHEMBL2127994 | 0.74 | HTR2A (0.47) | PARP1BRD4DRD4DRD3DRD2 | |
| SCHEMBL2496016 | 0.74 | PARP1 (0.35) | PARP1SMN1; SMN2 | |
| SCHEMBL20032408 | 0.73 | PARP1 (0.42) | PARP1BRD4DRD4DRD3DRD2 | |
| SCHEMBL2497545 | 0.73 | PARP1 (0.50) | PARP1BRD4 | |
| SCHEMBL2820806 | 0.72 | PARP1 (0.56) | PARP1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373628-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010070021-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-06-24 | — | — | WO | disclosed |