Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820806 | 0.86 | PARP1 (0.56) | PARP1CXCL8BRD4 | |
| SCHEMBL16740636 | 0.80 | PARP1 (0.43) | PARP1PRMT5 | |
| SCHEMBL7856459 | 0.80 | PARP1 (0.47) | PARP1PRMT5BRD4 | |
| SCHEMBL2611049 | 0.80 | PARP1 (0.46) | PARP1BRD4 | |
| SCHEMBL19100361 | 0.77 | MAPT (0.38) | PTGS2 | |
| SCHEMBL24351926 | 0.77 | PARP1 (0.44) | PARP1BRD4 | |
| SCHEMBL2497541 | 0.76 | CXCL8 (0.39) | PARP1CXCL8PTGS2 | |
| SCHEMBL2817256 | 0.75 | PARP1 (0.54) | PARP1BRD4 | |
| SCHEMBL2127998 | 0.74 | PARP1 (0.41) | PARP1BRD4 | |
| SCHEMBL18713659 | 0.74 | TSHR (0.42) | PARP1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373628-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010070021-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-06-24 | — | — | WO | disclosed |