Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22092692 | 0.88 | POLB (0.44) | NPC1RAB9AACP1MAPTNPSR1 | |
| SCHEMBL24987471 | 0.86 | POLB (0.46) | NPC1RAB9AMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL22092637 | 0.85 | KDM4E (0.41) | NPC1RAB9AMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL24961730 | 0.82 | MEN1 (0.43) | NPC1KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL22092671 | 0.78 | TYK2 (0.56) | POLBTYK2 | |
| SCHEMBL21887372 | 0.73 | TDP1 (0.44) | RAB9AKMT2AMEN1MAPTNPSR1 | |
| SCHEMBL21811164 | 0.73 | AKR1C3 (0.46) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL21887375 | 0.71 | KDM4E (0.42) | NPC1RAB9AMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL21887777 | 0.71 | MAPT (0.44) | NPC1RAB9AMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL21887781 | 0.70 | NPSR1 (0.43) | NPC1RAB9AKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3894412-B1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | LILLY CO ELI (US) | 2023-02-08 | — | — | EP | disclosed |