SCHEMBL2496274

SCHEMBL2496274

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nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 3/20 0.40
PYGM P11217 1/20 0.36
SLC5A2 P31639 2/20 0.36
ADORA3 P0DMS8 1/20 0.34
ADORA2A P29274 1/20 0.34
MAPT P10636 1/20 0.34
CDA P32320 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12212659 0.81 SLC5A2 (0.42) PYGMSLC5A2MAPTCDA
SCHEMBL2495634 0.81 SLC5A2 (0.42) PYGMSLC5A2MAPTCDA
SCHEMBL2497351 0.74 P2RY2 (0.34) ADORA1
SCHEMBL12212603 0.72 SLC5A2 (0.46) PYGMSLC5A2MAPTCDA
SCHEMBL13488831 0.70 PYGM (0.50) PYGMSLC5A2MAPTCDATDP1
SCHEMBL12697578 0.70 PYGM (0.50) PYGMSLC5A2MAPTCDATDP1
SCHEMBL2493918 0.70 PYGM (0.50) PYGMSLC5A2MAPTCDATDP1
SCHEMBL2497342 0.69 SLC29A1 (0.35)
SCHEMBL2495653 0.63 SLC5A2 (0.57) PYGMSLC5A2MAPTCDATDP1
SCHEMBL12212604 0.63 SLC5A2 (0.57) PYGMSLC5A2MAPTCDATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1970445-B1 METHOD FOR NUCLEIC ACID REPLICATION AND NOVEL ARTIFICIAL BASE PAIRS RIKEN (JP) 2012-09-26 EP disclosed
US-8030478-B2 Method for nucleic acid replication and novel artificial base pairs RIKEN (JP) 2011-10-04 US disclosed
US-20100036111-A1 METHOD FOR REPLICATING NUCLEIC ACIDS AND NOVEL UNNATURAL BASE PAIRS RIKEN (JP) 2010-02-11 US disclosed
EP-1970445-A1 METHOD FOR NUCLEIC ACID REPLICATION AND NOVEL ARTIFICIAL BASE PAIRS Riken (JP) 2008-09-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100036111-A1 METHOD FOR REPLICATING NUCLEIC ACIDS AND NOVEL UNNATURAL BASE PAIRS POLM, POLL, POLRMT ADORA1 1354/4885PYGM 2344/4885SLC5A2 3575/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.