Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24962592 | 0.74 | KMT2A (0.44) | LMNAPOLBPTGS1L3MBTL1MAPK1 | |
| SCHEMBL8296748 | 0.71 | LMNA (0.54) | LMNAPOLBPTGS1CES2CES1 | |
| SCHEMBL24964824 | 0.69 | LMNA (0.54) | LMNAPOLBCES2CES1CYP1A2 | |
| SCHEMBL15389739 | 0.68 | SMN1; SMN2 (0.49) | LMNAPOLBCES2CES1CYP1A2 | |
| SCHEMBL15389738 | 0.68 | SMN1; SMN2 (0.49) | LMNAPOLBCES2CES1CYP1A2 | |
| SCHEMBL24289761 | 0.68 | PARP1 (0.47) | POLBMEN1NPC1RAB9AKMT2A | |
| SCHEMBL18175181 | 0.67 | LMNA (0.50) | LMNAPOLBCES2CES1CYP2C19 | |
| SCHEMBL14754430 | 0.67 | TSHR (0.48) | LMNAPOLBCES2CES1TSHR | |
| SCHEMBL18962609 | 0.67 | LMNA (0.45) | LMNAPOLBCES2CES1CYP2C19 | |
| SCHEMBL8312011 | 0.67 | LMNA (0.50) | LMNACES2CES1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023004280-A1 | SELECTIVE PYRAZOLE LRRK2 INHIBITORS AND METHODS FOR USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-01-26 | — | — | WO | disclosed |