Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24962592 | 0.72 | KMT2A (0.44) | LMNAMAPTHTTSMN1; SMN2MEN1 | |
| SCHEMBL4411361 | 0.71 | PIK3CA (0.63) | PIK3CAMAPK13SMG1MAPK14NPC1 | |
| SCHEMBL21745904 | 0.70 | PIK3CA (0.53) | PIK3CAMAPK13MAPK14WNT1GSK3B | |
| SCHEMBL13958039 | 0.70 | PIK3CA (0.58) | PIK3CAMAPTHTTSMN1; SMN2SMG1 | |
| SCHEMBL3554847 | 0.70 | PIK3CA (0.76) | PIK3CAMAPK13MAPK14NPC1ALDH1A1 | |
| SCHEMBL29889392 | 0.70 | PIK3CA (0.76) | PIK3CAMAPK13MAPK14NPC1ALDH1A1 | |
| SCHEMBL1516927 | 0.70 | PIK3CA (0.76) | PIK3CAMAPK13MAPK14RAB9ANPC1 | |
| SCHEMBL19160077 | 0.70 | PIK3CA (0.76) | PIK3CAMAPK13MAPK14RAB9ANPC1 | |
| SCHEMBL19671689 | 0.70 | PIK3CA (0.46) | PIK3CAMAPK13MAPK14WNT1GSK3B | |
| SCHEMBL21444479 | 0.69 | PIK3CA (0.51) | PIK3CAMAPK13MAPTSMG1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023004280-A1 | SELECTIVE PYRAZOLE LRRK2 INHIBITORS AND METHODS FOR USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-01-26 | — | — | WO | disclosed |