Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24967155 | 0.85 | TLK2 (0.57) | MAPTKMT2APAK4MAP4K1PDPK1 | |
| SCHEMBL24967118 | 0.81 | NPC1 (0.55) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL30155085 | 0.81 | NPC1 (0.55) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL30155038 | 0.81 | NPC1 (0.55) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL24967157 | 0.81 | MAP4K1 (0.47) | MAPTKMT2ALRRK2MAP4K1PDPK1 | |
| SCHEMBL24966362 | 0.80 | TLK2 (0.58) | TLK2NTRK1 | |
| SCHEMBL15879182 | 0.78 | NPC1 (0.69) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL14375860 | 0.78 | NPC1 (0.69) | NPC1MAPTKMT2AGAATDP1 | |
| SCHEMBL24966377 | 0.78 | MEN1 (0.47) | MAPTKMT2AMAP4K1PDPK1RET | |
| SCHEMBL14335879 | 0.76 | KMT2A (0.69) | NPC1MAPTKMT2AGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001942-A1 | 14-3-3 PROTEIN MODULATORS AS ANTITUMOR AGENTS | RAPPOSELLI SIMONA (IT) | 2023-01-26 | — | — | WO | disclosed |