Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 8/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24967156 | 0.82 | PDPK1 (0.50) | MAP4K1GSK3BPDPK1 | |
| SCHEMBL30155032 | 0.82 | PDPK1 (0.50) | MAP4K1GSK3BPDPK1 | |
| SCHEMBL30155136 | 0.82 | PDPK1 (0.50) | MAP4K1GSK3BPDPK1 | |
| SCHEMBL24967155 | 0.81 | TLK2 (0.57) | MAP4K1MAPTPDPK1MEN1KMT2A | |
| SCHEMBL24967119 | 0.81 | NPC1 (0.56) | MAP4K1MAPTPDPK1MEN1KMT2A | |
| SCHEMBL24966362 | 0.79 | TLK2 (0.58) | TLK2 | |
| SCHEMBL24966377 | 0.77 | MEN1 (0.47) | MAP4K1GSK3BMAPTPDPK1MEN1 | |
| SCHEMBL6001134 | 0.71 | MAPT (0.62) | GSK3BAPPMAPTMEN1KMT2A | |
| SCHEMBL6001136 | 0.71 | MAPT (0.62) | GSK3BAPPMAPTMEN1KMT2A | |
| SCHEMBL3804991 | 0.68 | LRRK2 (0.75) | LRRK2EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001942-A1 | 14-3-3 PROTEIN MODULATORS AS ANTITUMOR AGENTS | RAPPOSELLI SIMONA (IT) | 2023-01-26 | — | — | WO | disclosed |