Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30851110 | 1.00 | LMNA (0.39) | LMNACFTRMAPTSMN1; SMN2AURKA | |
| SCHEMBL30851253 | 0.88 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2S1PR1GAA | |
| SCHEMBL24967935 | 0.88 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2S1PR1GAA | |
| SCHEMBL29165958 | 0.86 | LMNA (0.41) | LMNACFTRMAPTSMN1; SMN2AURKA | |
| SCHEMBL24967939 | 0.82 | HDAC4 (0.44) | LMNACFTRMAPTSMN1; SMN2KDM4E | |
| SCHEMBL29208803 | 0.81 | AURKA (0.39) | LMNACFTRMAPTAURKAKDR | |
| SCHEMBL21031170 | 0.80 | AURKA (0.40) | LMNACFTRMAPTAURKAKDR | |
| SCHEMBL24968231 | 0.79 | AURKA (0.37) | LMNACFTRMAPTAURKAKDR | |
| SCHEMBL24968228 | 0.79 | AURKA (0.37) | LMNACFTRMAPTAURKAKDR | |
| SCHEMBL30851115 | 0.79 | AURKA (0.37) | LMNACFTRMAPTAURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117642393-A | Novel PARP7 inhibitor and application thereof | 上海齐鲁制药研究中心有限公司 | 2024-03-01 | — | — | CN | disclosed |
| WO-2023006013-A1 | NOVEL PARP7 INHIBITOR AND USE THEREOF | 上海齐鲁制药研究中心有限公司 | 2023-02-02 | — | — | WO | disclosed |