Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27497542 | 0.89 | TDP1 (0.50) | MAP2K1TDP1KDM4EL3MBTL1PKM | |
| SCHEMBL9963329 | 0.86 | TDP1 (0.54) | MAP2K1TDP1KDM4EL3MBTL1PKM | |
| SCHEMBL16344365 | 0.83 | TDP1 (0.55) | MAP2K1TDP1KDM4EL3MBTL1PKM | |
| SCHEMBL9693906 | 0.80 | TDP1 (0.48) | MAP2K1TDP1KDM4EL3MBTL1PKM | |
| SCHEMBL25391378 | 0.79 | KDM4E (0.57) | TDP1KDM4EL3MBTL1LMNATSHR | |
| SCHEMBL18551398 | 0.78 | TDP1 (0.47) | MAP2K1TDP1KDM4EL3MBTL1PKM | |
| SCHEMBL28088585 | 0.78 | SLC6A3 (0.46) | MAP2K1TDP1KDM4EL3MBTL1PKM | |
| SCHEMBL29574644 | 0.77 | TDP1 (0.55) | MAP2K1TDP1KDM4EL3MBTL1PKM | |
| SCHEMBL111436 | 0.77 | TDP1 (0.55) | MAP2K1TDP1KDM4EL3MBTL1PKM | |
| SCHEMBL812065 | 0.77 | KDM4E (0.59) | MAP2K1TDP1KDM4EL3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4378938-A1 | NOVEL PARP7 INHIBITOR AND USE THEREOF | Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. (CN) | 2024-06-05 | — | — | EP | disclosed |
| CN-117642393-A | Novel PARP7 inhibitor and application thereof | 上海齐鲁制药研究中心有限公司 | 2024-03-01 | — | — | CN | disclosed |
| WO-2023006013-A1 | NOVEL PARP7 INHIBITOR AND USE THEREOF | 上海齐鲁制药研究中心有限公司 | 2023-02-02 | — | — | WO | disclosed |