⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24007149 | 0.81 | TAF1 (0.32) | — | |
| SCHEMBL24008093 | 0.75 | BMPR1B (0.40) | — | |
| SCHEMBL25745854 | 0.74 | BMPR1B (0.38) | — | |
| SCHEMBL24007631 | 0.74 | — | — | |
| SCHEMBL25745911 | 0.74 | — | — | |
| SCHEMBL24566229 | 0.73 | MEN1 (0.31) | — | |
| SCHEMBL24008142 | 0.73 | RET (0.32) | — | |
| SCHEMBL24007998 | 0.73 | QDPR (0.36) | — | |
| SCHEMBL24007996 | 0.72 | — | — | |
| SCHEMBL24007158 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265075-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. | 2023-08-24 | — | — | US | disclosed |
| WO-2023009712-A1 | HETEROARYLOXY THIAZOLO AZINES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2023009712-A1 | HETEROARYLOXY THIAZOLO AZINES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2023-02-02 | — | — | WO | disclosed |