Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.34 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24975688 | 0.84 | PDE10A (0.34) | PDE10ALRRK2TRPC6FYNPDGFRB | |
| SCHEMBL31739611 | 0.77 | DYRK1A (0.37) | FYN | |
| SCHEMBL31000264 | 0.75 | — | — | |
| SCHEMBL27332713 | 0.75 | NRAS (0.36) | TRPC6FYN | |
| SCHEMBL31639175 | 0.75 | NRAS (0.36) | TRPC6FYN | |
| SCHEMBL31639341 | 0.73 | PDE10A (0.34) | PDE10ALRRK2TRPC6KDM4EALDH1A1 | |
| SCHEMBL29682761 | 0.73 | FLT3 (0.42) | FYNPDGFRBPDGFRA | |
| SCHEMBL24542495 | 0.73 | FLT3 (0.42) | FYNPDGFRBPDGFRA | |
| SCHEMBL31000261 | 0.72 | IGF1R (0.38) | — | |
| SCHEMBL31000231 | 0.72 | NRAS (0.34) | TRPC6FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |