Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 13/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 7/20 | 0.49 |
| ▸ | NRAS | P01111 | 6/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.44 |
| ▸ | CDK7 | P50613 | 5/20 | 0.44 |
| ▸ | CCNH | P51946 | 5/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | BLK | P51451 | 2/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24977165 | 0.83 | IRAK4 (0.52) | IRAK4MAPK8FLT3IRAK1NRAS | |
| SCHEMBL24977161 | 0.77 | FLT3 (0.49) | IRAK4MAPK8FLT3IRAK1NRAS | |
| SCHEMBL30248481 | 0.77 | FLT3 (0.49) | IRAK4MAPK8FLT3IRAK1NRAS | |
| SCHEMBL24976668 | 0.77 | FLT3 (0.49) | IRAK4MAPK8FLT3IRAK1NRAS | |
| SCHEMBL24975877 | 0.77 | FLT3 (0.49) | IRAK4MAPK8FLT3IRAK1NRAS | |
| SCHEMBL24574413 | 0.76 | FLT3 (0.69) | IRAK4FLT3IRAK1NRASPDGFRB | |
| SCHEMBL24574346 | 0.76 | FLT3 (0.69) | IRAK4FLT3IRAK1NRASPDGFRB | |
| SCHEMBL24976207 | 0.75 | FLT3 (0.57) | IRAK4MAPK8FLT3IRAK1NRAS | |
| SCHEMBL31000113 | 0.74 | IRAK4 (0.51) | IRAK4MAPK8FLT3IRAK1NRAS | |
| SCHEMBL24976241 | 0.73 | IRAK4 (0.54) | IRAK4MAPK8FLT3IRAK1NRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |