Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 3/20 | 0.59 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23547108 | 0.88 | PIK3CB (0.59) | PIK3CBSLC22A12CYP19A1KEAP1NFE2L2 | |
| SCHEMBL22792319 | 0.86 | SLC22A12 (0.63) | PIK3CBSLC22A12CYP19A1KEAP1NFE2L2 | |
| SCHEMBL23547109 | 0.83 | SLC22A12 (0.52) | PIK3CBSLC22A12CYP19A1KEAP1NFE2L2 | |
| SCHEMBL24980451 | 0.76 | MEN1 (0.65) | SLC22A12LMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL22792095 | 0.74 | GAA (0.58) | SLC22A12CYP19A1KEAP1NFE2L2GAA | |
| SCHEMBL31011104 | 0.73 | SLC22A12 (0.51) | PIK3CBSLC22A12GAALMNASMN1; SMN2 | |
| SCHEMBL17858621 | 0.72 | MEN1 (0.60) | PIK3CBSLC22A12GAALMNASMN1; SMN2 | |
| SCHEMBL15648607 | 0.70 | PIK3CB (0.54) | PIK3CBCYP19A1KEAP1NFE2L2GAA | |
| SCHEMBL1055634 | 0.70 | MEN1 (0.65) | SLC22A12GAAALPLKMT2A | |
| SCHEMBL790294 | 0.70 | GAA (0.86) | CYP19A1KEAP1NFE2L2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230032020-A1 | SMALL-MOLECULE COVALENT INHIBITION OF RAL GTPASES | NATIONAL INSTITUTES OF HEALTH | 2023-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230032020-A1 | SMALL-MOLECULE COVALENT INHIBITION OF RAL GTPASES | RALA, KRAS, HRAS | PIK3CB 1170/4885SLC22A12 2727/4885CYP19A1 4370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.