SCHEMBL24980462

SCHEMBL24980462

CC1(C)O[C@@H]2[C@@H](CO[Si](C)(C)C(C)(C)C)OC(n3cnc4c(N)nc(F)nc43)[C@@H]2O1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.54
PI4KA P42356 1/20 0.52
PI4K2B Q8TCG2 1/20 0.52
PI4K2A Q9BTU6 1/20 0.52
PI4KB Q9UBF8 1/20 0.52
NT5E P21589 2/20 0.49
LMNA P02545 1/20 0.49
HIF1A Q16665 1/20 0.49
P2RX1 P51575 2/20 0.48
P2RX3 P56373 2/20 0.48
P2RX4 Q99571 2/20 0.48
CA5A P35218 1/20 0.48
AMD1 P17707 2/20 0.44
ADORA3 P0DMS8 3/20 0.42
ADORA2A P29274 2/20 0.42
ADORA2B P29275 2/20 0.42
ADORA1 P30542 1/20 0.42
AHCY P23526 1/20 0.41
DNMT1 P26358 1/20 0.41
DNMT3B Q9UBC3 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14174699 0.90 RXFP1 (0.53) RXFP1PI4KAPI4K2BPI4K2API4KB
SCHEMBL5052460 0.90 RXFP1 (0.53) RXFP1PI4KAPI4K2BPI4K2API4KB
SCHEMBL5052456 0.90 RXFP1 (0.53) RXFP1PI4KAPI4K2BPI4K2API4KB
SCHEMBL18493296 0.89 ADORA3 (0.53) RXFP1PI4KAPI4K2BPI4K2API4KB
SCHEMBL30546911 0.86 PI4KA (0.70) RXFP1PI4KAPI4K2BPI4K2API4KB
SCHEMBL2291014 0.86 PI4KA (0.70) RXFP1PI4KAPI4K2BPI4K2API4KB
SCHEMBL25756772 0.86 PI4KA (0.70) RXFP1PI4KAPI4K2BPI4K2API4KB
SCHEMBL24146635 0.86 PI4KA (0.70) RXFP1PI4KAPI4K2BPI4K2API4KB
SCHEMBL21377709 0.86 PI4KA (0.70) RXFP1PI4KAPI4K2BPI4K2API4KB
SCHEMBL25756742 0.86 PI4KA (0.70) RXFP1PI4KAPI4K2BPI4K2API4KB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023000708-A1 POLYSUBSTITUTED PURINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF 中国药科大学 2023-01-26 WO disclosed