Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 12/20 | 0.53 |
| ▸ | DRD4 | P21917 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24985379 | 0.92 | LMNA (0.53) | LMNAMAPTGFERGRM2DRD4 | |
| SCHEMBL30163836 | 0.90 | LMNA (0.56) | LMNAMAPTGFERGRM2DRD4 | |
| SCHEMBL24985186 | 0.86 | LMNA (0.49) | LMNAMAPTGFERGRM2DRD4 | |
| SCHEMBL30164100 | 0.86 | LMNA (0.49) | LMNAMAPTGFERGRM2DRD4 | |
| SCHEMBL24984557 | 0.84 | GRM2 (0.67) | LMNAMAPTGFERGRM2DRD4 | |
| SCHEMBL24984225 | 0.81 | LMNA (0.64) | LMNAMAPTGFERGRM2DRD4 | |
| SCHEMBL24985451 | 0.80 | LMNA (0.54) | LMNAMAPTGFERGRM2DRD4 | |
| SCHEMBL24985380 | 0.78 | LMNA (0.50) | LMNAMAPTGFERGRM2DRD4 | |
| SCHEMBL30164161 | 0.78 | LMNA (0.50) | LMNAMAPTGFERGRM2DRD4 | |
| SCHEMBL24985481 | 0.78 | RXFP1 (0.44) | LMNAMAPTGFERGRM2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006893-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | CONFO THERAPEUTICS N.V. (BE) | 2023-02-02 | — | — | WO | disclosed |