Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.52 |
| ▸ | DRD4 | P21917 | 9/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30163934 | 1.00 | GRM2 (0.52) | GRM2DRD4DRD2DRD3CXCR3 | |
| SCHEMBL24985228 | 0.89 | LMNA (0.50) | GRM2DRD4CXCR3KDM4EOPRM1 | |
| SCHEMBL30164061 | 0.89 | LMNA (0.50) | GRM2DRD4CXCR3KDM4EOPRM1 | |
| SCHEMBL30164155 | 0.88 | GRM2 (0.51) | GRM2DRD4DRD2DRD3 | |
| SCHEMBL24985173 | 0.88 | GRM2 (0.51) | GRM2DRD4DRD2DRD3 | |
| SCHEMBL29232145 | 0.86 | GRM2 (0.54) | GRM2DRD4DRD2DRD3CXCR3 | |
| SCHEMBL30164146 | 0.86 | GRM2 (0.54) | GRM2DRD4DRD2DRD3CXCR3 | |
| SCHEMBL30164034 | 0.81 | GRM2 (0.64) | GRM2DRD4DRD2DRD3KDM4E | |
| SCHEMBL30164125 | 0.77 | AGTR2 (0.54) | GRM2LMNAGAAALDH1A1NPSR1 | |
| SCHEMBL29232389 | 0.77 | AGTR2 (0.54) | GRM2LMNAGAAALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118159530-A | Compounds for the treatment of pain, in particular neuropathic pain and/or other diseases or disorders associated with AT2R and/or AT2R mediated signalling | 康福治疗有限公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2023006893-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | CONFO THERAPEUTICS N.V. (BE) | 2023-02-02 | — | — | WO | disclosed |