⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochlorthiazide SCHEMBL450348 | 0.96 | — | — | |
| Hydrochlorthiazide SCHEMBL3110285 | 0.96 | — | — | |
| Hydrochlorthiazide SCHEMBL9336266 | 0.96 | — | — | |
| Hydrochlorthiazide SCHEMBL6291 | 0.96 | — | — | |
| Hydrochlorthiazide SCHEMBL25294605 | 0.93 | — | — | |
| Hydrochlorthiazide SCHEMBL250706 | 0.93 | — | — | |
| Hydrochlorthiazide SCHEMBL271146 | 0.93 | — | — | |
| Hydrochlorthiazide SCHEMBL291944 | 0.93 | — | — | |
| Hydrochlorthiazide SCHEMBL8981983 | 0.93 | — | — | |
| Hydrochlorthiazide SCHEMBL2230375 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113264902-A | Synthesis production process of lithium thiazole | 南京爱可德夫科技开发有限公司 | 2021-08-17 | — | — | CN | claimed |
| JP-10045732-A | — | — | None | — | — | JP | disclosed |
| CN-116554121-A | Synthesis method of 2-isobutyl thiazole | 济南悟通生物科技有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-219400107-U | Synthesis system of 2-acetyl thiazole | 济南悟通生物科技有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-219400107-U | Synthesis system of 2-acetyl thiazole | 济南悟通生物科技有限公司 | 2023-07-25 | — | — | CN | disclosed |
| US-11691959-B2 | Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds | AVEXXIN AS (NO) | 2023-07-04 | — | — | US | disclosed |
| CN-112898226-B | Preparation method of 2-alkyl substituted thiazole compound | 济南悟通生物科技有限公司 | 2023-02-24 | — | — | CN | disclosed |
| US-20220363659-A1 | ANTI-INFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | AVEXXIN AS (NO) | 2022-11-17 | — | — | US | disclosed |
| CN-107074840-B | 2-oxothiazole compounds having activity as cPLA2 inhibitors for the treatment of inflammatory and hyperproliferative diseases | 埃维克辛公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-113264902-A | Synthesis production process of lithium thiazole | 南京爱可德夫科技开发有限公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-1121379-C | Synthesis and use of retinoid having negative hormone and/or antagonist activity | ALLERGAN CO (US) | 2003-09-17 | — | — | CN | disclosed |
| CN-1360890-A | Use of active retiene derivative with negative hormone and/or antagonist | ALLERGAN INC (US) | 2002-07-31 | — | — | CN | disclosed |
| CN-1268130-A | Synthesis and use of retinol derivative compounds having negative hormone and/or antagonist activity | ALLERGAN SALES INC (US) | 2000-09-27 | — | — | CN | disclosed |
| US-6124291-A | TREATING AND PREVENTING THROMBOTIC DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-09-26 | — | — | US | disclosed |
| CN-1212705-A | Serine protease inhibitors | AKZO NOBEL NV (NL) | 1999-03-31 | — | — | CN | disclosed |
| CN-1209802-A | Synthesis and use of retinoid having negative hormone and/or antagonist activity | ALLERGAN CO (US) | 1999-03-03 | — | — | CN | disclosed |
| EP-0846120-A1 | LOW MOLECULAR WEIGHT BICYCLIC-AREA TYPE THROMBIN INHIBITORS | BIOCHEM PHARMA INC (CA) | 1998-06-10 | — | — | EP | disclosed |
| JP-H1045732-A | DIARYLETHENE DERIVATIVE AND PHOTOCHROMIC MATERIAL USING THE SAME | IRIE MASAHIRO | 1998-02-17 | — | — | JP | disclosed |
| WO-1997048706-A1 | PYRROLO[1,2-A]PYRAZINE-1,4-DIONE SERINE PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |
| WO-1996037497-A1 | LOW MOLECULAR WEIGHT BICYCLIC-UREA TYPE THROMBIN INHIBITORS | BIOCHEM PHARMA INC. (CA) | 1996-11-28 | — | — | WO | disclosed |