Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 13/20 | 0.53 |
| ▸ | DRD4 | P21917 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24984206 | 0.89 | GRM2 (0.55) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL24985379 | 0.85 | LMNA (0.53) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL24984230 | 0.84 | GRM2 (0.67) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL24984225 | 0.83 | LMNA (0.64) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL24986937 | 0.83 | GRM2 (0.64) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL24985352 | 0.83 | GRM2 (0.54) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL24985451 | 0.82 | LMNA (0.54) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL24985411 | 0.79 | GRM2 (0.50) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL31185267 | 0.79 | GRM2 (0.50) | GRM2DRD4KDM4EOPRM1OPRD1 | |
| SCHEMBL24985188 | 0.76 | LMNA (0.54) | GRM2DRD4KDM4EOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006893-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | CONFO THERAPEUTICS N.V. (BE) | 2023-02-02 | — | — | WO | disclosed |