Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9893626 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBPLA2G1B | |
| SCHEMBL37787 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBPLA2G1B | |
| SCHEMBL29209175 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBPLA2G1B | |
| SCHEMBL28664577 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBPLA2G1B | |
| SCHEMBL22986852 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBPLA2G1B | |
| SCHEMBL4798727 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBPLA2G1B | |
| SCHEMBL4797069 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBPLA2G1B | |
| SCHEMBL37601 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBPLA2G1B | |
| SCHEMBL14840061 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBPLA2G1B | |
| SCHEMBL14840100 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023014979-A9 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR KRAS G12C PROTEINS | RAYZEBIO, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023014979-A1 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR KRAS G12C PROTEINS | RAYZEBIO, INC. (US) | 2023-02-09 | — | — | WO | disclosed |