Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CDC42 | P60953 | 1/20 | 0.52 |
| ▸ | RAC1 | P63000 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29960316 | 1.00 | CXCR2 (0.54) | CXCR2PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL18770103 | 0.88 | AKR1C3 (0.64) | CXCR2PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL1822574 | 0.88 | CXCR2 (0.68) | CXCR2PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL1820336 | 0.85 | PTGS1 (0.53) | CXCR2PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL19600946 | 0.84 | CXCR2 (0.51) | CXCR2PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL29403959 | 0.80 | TDP1 (0.77) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL29508603 | 0.80 | TDP1 (0.77) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL505819 | 0.80 | TDP1 (0.77) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL505811 | 0.80 | TDP1 (0.77) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL505799 | 0.80 | TDP1 (0.77) | PTGS2AKR1C3AKR1C2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230039244-A1 | 2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME | UNIV PENNSYLVANIA (US) | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230039244-A1 | 2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME | AKR1C3, AKR1C2, AKR1A1 | CXCR2 2053/4885PTGS2 261/4885AKR1C3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.