Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | ALPI | P09923 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24993368 | 0.87 | MAPT (0.49) | KDM4ENPC1RAB9AALPLALPI | |
| SCHEMBL24994721 | 0.83 | RAB9A (0.47) | KDM4ENPC1RAB9AMAPTHPGD | |
| SCHEMBL24994733 | 0.81 | NPC1 (0.46) | KDM4ENPC1RAB9AMAPTHPGD | |
| SCHEMBL24994723 | 0.81 | ALDH1A1 (0.48) | KDM4ENPC1RAB9AMAPTHPGD | |
| SCHEMBL24994714 | 0.81 | NPC1 (0.46) | KDM4ENPC1RAB9AMAPTHPGD | |
| SCHEMBL24994722 | 0.81 | NPC1 (0.46) | KDM4ENPC1RAB9AMAPTHPGD | |
| SCHEMBL29215098 | 0.78 | MEN1 (0.46) | KDM4ENPC1RAB9AMAPTHPGD | |
| SCHEMBL29215094 | 0.78 | MEN1 (0.46) | KDM4ENPC1RAB9AMAPTHPGD | |
| SCHEMBL30925906 | 0.78 | MEN1 (0.46) | KDM4ENPC1RAB9AMAPTHPGD | |
| SCHEMBL25002920 | 0.74 | NPC1 (0.52) | KDM4ENPC1RAB9AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010191-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |