Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | TPO | P07202 | 1/20 | 0.37 |
| ▸ | EPX | P11678 | 1/20 | 0.37 |
| ▸ | LPO | P22079 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | PNLIP | P16233 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30879388 | 0.84 | DYRK1A (0.42) | DYRK1ASCN5AJAK2MEN1KMT2A | |
| SCHEMBL1192681 | 0.84 | DYRK1A (0.42) | DYRK1ASCN5AJAK2MEN1KMT2A | |
| SCHEMBL12524904 | 0.84 | SCN5A (0.39) | DYRK1ASCN5AJAK2SLC6A4HTR2A | |
| SCHEMBL3484112 | 0.82 | EGFR (0.38) | PDE7AMPOTPOEPXLPO | |
| SCHEMBL29887886 | 0.82 | EGFR (0.38) | PDE7AMPOTPOEPXLPO | |
| SCHEMBL15703638 | 0.81 | CYP2C19 (0.40) | DYRK1ASCN5AJAK2HDAC1HDAC8 | |
| SCHEMBL12872522 | 0.80 | ALDH1A1 (0.47) | DYRK1ASCN5AMEN1KMT2ANPC1 | |
| SCHEMBL30879425 | 0.79 | PDE7A (0.55) | PDE7AMEN1KMT2ANPC1CYP3A4 | |
| SCHEMBL3483796 | 0.78 | PDE7A (0.41) | PDE7ASCN5AMPOTPOEPX | |
| SCHEMBL23817200 | 0.76 | CYP3A4 (0.33) | DYRK1APDE7AJAK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980309-A | Tricyclic fused pyrimidine compounds useful as HER2 inhibitors | 百时美施贵宝公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023015240-A1 | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS FOR USE AS HER2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-02-09 | — | — | WO | disclosed |