Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | PNLIP | P16233 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | TPO | P07202 | 1/20 | 0.35 |
| ▸ | EPX | P11678 | 1/20 | 0.35 |
| ▸ | LPO | P22079 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21563126 | 0.83 | EGFR (0.42) | DRD2DRD4DRD3HTR2ASLC6A4 | |
| SCHEMBL3484150 | 0.82 | DRD2 (0.38) | PDE7ADRD2DRD4DRD3HTR2A | |
| SCHEMBL15701545 | 0.82 | CYP2C19 (0.39) | DRD2DRD4DRD3HTR2ADRD1 | |
| SCHEMBL3484788 | 0.80 | PDE7A (0.56) | PDE7AMEN1KMT2ACYP3A4NPC1 | |
| SCHEMBL24995754 | 0.78 | DYRK1A (0.42) | PDE7AHTR2ASLC6A4PNLIPMPO | |
| SCHEMBL4318630 | 0.75 | PDE7A (0.63) | PDE7AHTR2ASLC6A4PNLIPMEN1 | |
| SCHEMBL631854 | 0.72 | PDE7A (0.49) | PDE7AHTR2ASLC6A4PNLIPMPO | |
| SCHEMBL3483989 | 0.72 | AXL (0.41) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL1374919 | 0.72 | CYP3A4 (0.58) | PDE7APNLIPMEN1KMT2ACYP3A4 | |
| SCHEMBL554722 | 0.72 | MAOA (0.61) | PDE7AHTR2ASLC6A4PNLIPMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004238-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-2103620-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004238-A1 | FUSED HETEROCYCLIC COMPOUND | ERBB2, ROS1, FLT3 | PDE7A 4340/4885DRD2 1841/4885DRD4 2385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.