Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25001715 | 0.91 | EGFR (0.61) | EGFRBTKALK | |
| SCHEMBL25001407 | 0.86 | EGFR (0.54) | EGFRBTKALKCDK19MAP4K1 | |
| SCHEMBL25821603 | 0.86 | EGFR (0.53) | EGFRBTKALKCDK19MAP4K1 | |
| SCHEMBL25002853 | 0.85 | EGFR (0.47) | EGFRBTKALKCDK19MAP4K1 | |
| SCHEMBL30523214 | 0.80 | EGFR (0.54) | EGFRBTKALKCDK19MAP4K1 | |
| SCHEMBL25001806 | 0.79 | EGFR (0.49) | EGFRBTKALKMAP4K1 | |
| SCHEMBL23442859 | 0.79 | EGFR (0.61) | EGFRBTKALKMAP4K1 | |
| SCHEMBL29084096 | 0.78 | EGFR (0.71) | EGFRBTKALKCDK19MAP4K1 | |
| SCHEMBL25001347 | 0.77 | EGFR (0.63) | EGFRBTKALKMAP4K1AXL | |
| SCHEMBL27091454 | 0.77 | EGFR (0.74) | EGFRBTKALKCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4129996-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-02-08 | — | — | EP | disclosed |