Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.71 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.59 |
| ▸ | INSR | P06213 | 6/20 | 0.59 |
| ▸ | IGF1R | P08069 | 6/20 | 0.59 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 2/20 | 0.54 |
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.53 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | STK25 | O00506 | 1/20 | 0.52 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | CASK | O14936 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | MUSK | O15146 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27091519 | 0.91 | EGFR (0.67) | EGFRALKINSRIGF1RBTK | |
| SCHEMBL29084045 | 0.91 | EGFR (0.67) | EGFRALKINSRIGF1RBTK | |
| SCHEMBL29084036 | 0.91 | EGFR (0.65) | EGFRALKINSRIGF1RBTK | |
| SCHEMBL29084069 | 0.90 | EGFR (0.64) | EGFRALKINSRIGF1RBTK | |
| SCHEMBL29974926 | 0.89 | EGFR (0.65) | EGFRALKINSRIGF1RBTK | |
| SCHEMBL29974578 | 0.89 | EGFR (0.62) | EGFRBTKAXLCHEK1AURKA | |
| SCHEMBL23442003 | 0.88 | EGFR (0.61) | EGFRALKINSRIGF1RBTK | |
| SCHEMBL29083946 | 0.88 | EGFR (0.63) | EGFRALKINSRIGF1RBTK | |
| SCHEMBL29083940 | 0.88 | EGFR (0.61) | EGFRALKINSRIGF1RBTK | |
| SCHEMBL25001347 | 0.88 | EGFR (0.63) | EGFRALKINSRIGF1RBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670127-A | EGFR inhibitors and compositions and uses thereof | 贝达药业股份有限公司 | 2023-08-29 | — | — | CN | claimed |
| WO-2022206797-A1 | EGFR INHIBITOR, AND COMPOSITION AND USE THEREOF | 贝达药业股份有限公司 | 2022-10-06 | — | — | WO | claimed |
| CN-116670127-A | EGFR inhibitors and compositions and uses thereof | 贝达药业股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022206797-A1 | EGFR INHIBITOR, AND COMPOSITION AND USE THEREOF | 贝达药业股份有限公司 | 2022-10-06 | — | — | WO | disclosed |