Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.63 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA7 | P43166 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | XDH | P47989 | 4/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715051 | 0.88 | ATM (0.69) | CYP11B2CYP11B1ATMCA12CA1 | |
| SCHEMBL1179546 | 0.87 | CYP11B1 (0.76) | CYP11B2CYP11B1ATMCA12CA1 | |
| SCHEMBL2906199 | 0.86 | CYP11B1 (0.62) | CYP11B2CYP11B1ATMCYP2A6XDH | |
| SCHEMBL5326283 | 0.86 | CYP11B1 (0.79) | CYP11B2CYP11B1ATMCA1CA2 | |
| SCHEMBL4592444 | 0.86 | CYP11B1 (0.62) | CYP11B2CYP11B1ATMCYP2A6XDH | |
| SCHEMBL9008962 | 0.85 | CYP11B1 (0.61) | CYP11B2CYP11B1ATMCYP2A6XDH | |
| SCHEMBL641553 | 0.84 | CYP11B1 (0.60) | CYP11B2CYP11B1ATMCYP2A6XDH | |
| SCHEMBL31418026 | 0.83 | CYP11B1 (0.59) | CYP11B2CYP11B1ATMCA12CA1 | |
| SCHEMBL13188366 | 0.83 | CYP11B1 (0.67) | CYP11B2CYP11B1ATMCYP2A6MKNK1 | |
| SCHEMBL640445 | 0.82 | CYP11B1 (0.58) | CYP11B2CYP11B1ATMCYP2A6XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118076347-A | N-acylhydrazone compounds capable of inhibiting NAV 1.7 and/or NAV 1.8, methods of making, compositions, uses, methods of treatment and kits using the same | 欧罗法玛实验室股份公司 | 2024-05-24 | — | — | CN | disclosed |
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |