Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.62 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.62 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 5/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | ALPL | P05186 | 2/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | XDH | P47989 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715051 | 0.87 | ATM (0.69) | CYP11B1CYP11B2ATMCYP2A6XDH | |
| SCHEMBL25002964 | 0.86 | CYP11B2 (0.63) | CYP11B1CYP11B2MAP4K4ATMCYP2A6 | |
| SCHEMBL4432846 | 0.85 | CYP11B1 (0.63) | CYP11B1CYP11B2SCN10AATMCYP2A6 | |
| SCHEMBL2906199 | 0.84 | CYP11B1 (0.62) | CYP11B1CYP11B2SCN10AATMCYP2A6 | |
| SCHEMBL5326283 | 0.84 | CYP11B1 (0.79) | CYP11B1CYP11B2SCN10AMAP4K4ATM | |
| SCHEMBL30415838 | 0.84 | MKNK1 (0.65) | CYP11B1CYP11B2MAP4K4ALPLMKNK1 | |
| SCHEMBL21392047 | 0.84 | MKNK1 (0.65) | CYP11B1CYP11B2MAP4K4ALPLMKNK1 | |
| SCHEMBL9008962 | 0.84 | CYP11B1 (0.61) | CYP11B1CYP11B2ATMCYP2A6XDH | |
| SCHEMBL4592371 | 0.84 | CYP11B1 (0.58) | CYP11B1CYP11B2ATMALPLCYP2A6 | |
| SCHEMBL641553 | 0.83 | CYP11B1 (0.60) | CYP11B1CYP11B2MAP4K4ATMCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |
| US-7429605-B2 | Phenylpyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-09-30 | — | — | US | disclosed |
| CN-101213186-A | Phenylpyridine derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | CN | disclosed |
| EP-1912969-A1 | PHENYLPYRIDINE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007017169-A1 | PHENYLPYRIDINE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-15 | — | — | WO | disclosed |
| US-20070032530-A1 | Phenylpyridine derivatives | HOFFMANN-LA ROCHE INC. | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032530-A1 | Phenylpyridine derivatives | CYP3A5, QDPR, DPYD | CYP11B1 127/4885CYP11B2 103/4885SCN10A 1868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.