Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.56 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.47 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925964 | 0.88 | KEAP1 (0.58) | KEAP1NFE2L2ANPEPDPP8DPP7 | |
| SCHEMBL30600458 | 0.88 | KEAP1 (0.58) | KEAP1NFE2L2ANPEPDPP8DPP7 | |
| SCHEMBL4413196 | 0.88 | KEAP1 (0.58) | KEAP1NFE2L2ANPEPDPP8DPP7 | |
| SCHEMBL9331674 | 0.88 | KEAP1 (0.58) | KEAP1NFE2L2ANPEPDPP8DPP7 | |
| SCHEMBL17073673 | 0.88 | KEAP1 (0.58) | KEAP1NFE2L2ANPEPDPP8DPP7 | |
| SCHEMBL29400837 | 0.85 | KEAP1 (0.57) | KEAP1NFE2L2ANPEPDPP8DPP7 | |
| SCHEMBL30600462 | 0.85 | KEAP1 (0.57) | KEAP1NFE2L2ANPEPDPP8DPP7 | |
| SCHEMBL6281421 | 0.84 | DPP8 (0.59) | KEAP1NFE2L2ANPEPDPP8DPP7 | |
| SCHEMBL5204177 | 0.84 | KEAP1 (0.54) | KEAP1NFE2L2ANPEPDPP8DPP7 | |
| SCHEMBL9752156 | 0.84 | KEAP1 (0.54) | KEAP1NFE2L2ANPEPDPP8DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230045142-A1 | SMALL MOLECULE RPN13 INHIBITORS WITH ANTITUMOR PROPERTIES | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230045142-A1 | SMALL MOLECULE RPN13 INHIBITORS WITH ANTITUMOR PROPERTIES | MRPS23, RPP30, RPS19 | KEAP1 1826/4885NFE2L2 3000/4885ANPEP 1976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.